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Aldara Cream, containing Imiquimod 5mg, is a popular medication for treating many types of skin conditions, and is used [on the skin only] to treat Acitinic Keratosis, superficial Basal Cell Carcinoma, Genital and Perianal warts. It can be used in children above 12 for treating Genital or Perianal Warts, but in the other two conditions it is recommended only for adults with a healthy immune function.

Imiquimod activates the immune cells in the body into releasing cytokines like interferon. These cytokines strengthen the body's immune response to infection by preventing viral replication and further advancement of such cells. It makes possible the timely detection of hitherto hidden lesions.

Usage of Aldara cream makes possible the detection of previously hidden lesions, as in Acitinic Keratosis [AK] and superficial Basal Cell Carcinoma [sBCC], making it possible for these to be treated in time. It is also useful in treating Genital warts [GW], Perianal warts [PW], as well as infections that are caused by the Human Papillomavirus [HPV], some strains of which are responsible for causing GW.

Mostly fair-complexioned people or those who’ve had over-exposure to strong lights can develop itchy, reddish-brown, yellowish-black, or skin-colored flat and dry patches on the skin, which can be teeny-weeny or maybe an inch in width, in AK. If this condition is not treated, it can develop into a cancer of the skin - Squamous Cell Cancer. Aldara can be used in people with AK provided they have a normal immune function.

Over-exposure to the sunlight or strong lights can cause sBCC, which is a common skin cancer, and manifests itself in lesions, maybe new, or a change in an older growth, or a bleeding open sore. If detected in time, this condition can easily be treated with Aldara.

GW and PW occur in the genital and anus areas in men and women as growths or bumps, either singly, or in clusters, which are mostly painless. They can vary in size, and blend with the skin. As certain strains of HPV are responsible for causing GW - which can be sexually transmitted - and once these have been detected, it is essential for both partners to be treated otherwise the single treated partner can be re-infected.

The recommended use of Aldara is once daily, 2-5 days a week, depending on the skin condition. The treatment can last for a period of 6-16 weeks for the same reason. Check with your doctor/dermatologist for clear instructions regarding the application schedule, and stick to that.

Before and after applying the cream, wash your hands with soap and water. The infected area also should be washed with a mild soap and water; allow this to completely dry before you apply the cream. It’s best to apply this cream at night, so that it works on the skin for a good 6-8 hours, after which you have to wash the treated area with a mild soap and water.

Apply a thin layer only, gently rubbing it in to the infected area. This is meant for the skin only, so do not let this cream enter any open wounds, lips, nostrils, or eyes. Don't cover the treated area with a bandage or closed dressing; only cotton gauze or cotton undergarments are permissible

The less serious side effects can include:-

• Reddening or flaking of the skin;


• Crusting;


• Change in skin color.

An allergic reaction to the skin can cause:- Swelling, Itching, or a Burning sensation in the skin, for which you must talk to your doctor at once.

Seek emergency medical help if any symptom persists or bothers you, and especially if you experience any unusual or serious side effects such as:-
Headaches,Muscular pain, Backache, S wollen lymph nodes, Flu-like symptoms,Diarrhea,Fungal infections.

Over-application
If you think you’ve over-applied this Cream, and experience any symptom that is bothering you, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222.

Interaction

Imiquimod interacts with other medicines and certain conditions. While your doctor can give you complete information, some of the medications and conditions in which this medicine should not be taken, include:-

• Medicines for treating auto-immune disorders;


• Medicines for treating hypertension;


• An allergy to Imiquimod.

Medical conditions in which this cream should not be applied, include:-

• Psoriasis - an inflammatory skin condition;


• Someone who has had a recent surgery and developed a skin condition where the surgery took place, must wait for the operated area to be completely healed before Imiquimod is used;


• A condition when a patient suffers from a chronic graft-versus-host disease, in which, the transplanted cells take the host tissue to be "foreign" and attack it.

Precautions

• Inform the doctor about all the ailments you have suffered from, especially if you have psoriasis [which Imiquimod can make worse], any autoimmune disease, hypertension, if you have recently undergone a surgery that remains unhealed in the area to be treated, or if you are taking any other treatment for AK-sBCC-GW-PW-other skin problem.


• Before beginning treatment with Aldara Cream, inform the doctor about all the medicines [including prescription and OTC]-herbal products-nutritional supplements you take, and whether you are allergic to any medicine, so that the doctor can prescribe the correct dosage for you.


• Pregnant women, those who are lactating, or those who are planning to have a child, must use this cream only if their doctor tells them to do so.


• It is recommended that mating should be refrained from in an individual who has GW, because as long as the cream remains on the skin, it can weaken condoms or diaphragms.


• Aldara can make people more sensitive to sunlight or strong lights, so those who use it for AK or sBCC, should avoid exposure to the sun or strong lights, and use protective clothing, to derive benefit of this cream.

Do not begin, increase, decrease, or stop the medicine on your own. Do not share your medicine with others even if they have the same symptoms as you, for it can harm them.

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Also if you have any surgery or medical treatment for any skin conditions, inform your doctor about the same, prior to starting treatment with this medicine.

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As per your doctors advice, apply your next dose as directed, do not double applications to make up for a missed one. Follow the schedule as directed by your doctor.

Since it is only a one-time application – usually at night – it is not likely that you will forget to apply the cream. If you do miss making an application, check with your doctor, for the application schedule differs according to the skin condition.

Aldara Cream should be stored at a room temperature below 25oC. You can refrigerate the cream, but do not freeze it. Any frozen packet should be properly discarded, as well as any partly used packet.

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