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  • Brand:Vytorin Generic
  • Composition:EZETIMIBE and SIMVASTATIN
 
 
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  • Vytorin Description

    This medicine is used for the management of the cholesterol levels in the body. Ezetimibe is a lipid-lowering compound that inhibits absorption of cholesterol at the border of the small intestine, reducing hepatic cholesterol and clearing it. Simvastatin is a statin that blocks the HMG-CoA enzyme in the liver, preventing cholesterol synthesis from occurring. It also leads to an increased expulsion of low-density lipoprotein - LDL [ bad" cholesterol], reduces triglycerides [a kind of fat in the blood/fat tissue], and raises the production of high-density lipoprotein - HDL [ good" cholesterol].

    Vytorin lessens the chances of heart attack, stroke and circulatory problems that are caused by imbalance of cholesterol.
  • Uses of Generic Ezetimibe and Simvastatin

    The combined strength of Ezitimibe and Simvastatin lowers the risk in individuals of contracting heart disease, stroke and circulatory problems. This medication is given to adults and children who are above 10.
  • Missed Dose

    It's a single dose normally, so try to take it at the same time daily. If you do miss a dose, try to take it soon provided there is sufficient time for the next one, otherwise leave out the missed dose and take the regular one, but don't double your dose.
  • Side effects

    Some of the common, less serious side effects may include:-

    • Headache;

    • Diarrhea;

    • Constipation;

    • Nausea;

    • Vomiting;

    • Joint pains;

    • Tingling sensation.



    If you have an allergic reaction such as:- itching, rash, swelling in the face/lips/tongue/throat, stop the medicine and ask your doctor for help.

    If any symptom persists or gets worse, or if any other serious or unusual symptoms occur such as the following, contact the physician and seek emergency help immediately:

    • Difficulty in breathing;

    • Persistent nausea;

    • Dizziness;

    • Blurred vision;

    • Tachycardia [rapid heartbeat];

    • Extreme tiredness;

    • Jaundice;

    • Changes in urinary output/dark urine;

    • Clay-colored stools;

    • Insomnia;

    • Muscular pain/tenderness/weakness.
  • Overdose

    An overdose of this medicine is not likely to be life-threatening, but if something bothers you, or you think you've taken an overdose, contact your local poison control center or emergency room at once. US residents can call the US national poison hotline at 1-800-222-1222.
  • Interactions

    Some of the medicines with which Ezetimibe-Simvastatin interact, are:-

    • Cholesterol reducing medicines such as Cholestyramine;

    • Antiarrhythmic medications such as Amiodarone;

    • Calcium channel blockers like Verapamil, for treating angina and arrhythmias;

    • Heart medications like Digoxin, for treating congestive heart failure and atrial fibrillation;

    • Synthetic hormones like Danazol, for treating endometriosis;

    • Immunosuppressants like Ciclosporin;

    • Anticoagulants such as Warfarin;

    • Large amounts of Grapefruit/grapefruit juice.
  • Storage

    After you buy Vytorin, store it at a room temperature of 20°C-25°C, safe from heat, light and dampness. Keep it out of reach of children and pets.

  • Dosage of Vytorin

    The dose is not only different for adults and children, but it also depends on the medical condition of the patient. Take the dose as directed by the physician/pediatrician. The medicine should be taken once every evening with water, with or without meals. The doctor may give a higher dose if the LDL levels are very high.
  • Precautions

    • Before treatment begins, patients [or their parents] must inform the doctor/pediatrician of their medical history, particularly if you suffer from low blood pressure, seizures, trauma, any severe metabolic disorder [like diabetes], endocrine disorder [like hypothyroidism], electrolyte disorder, any kidney/liver disease, if you've had any surgery, or drink heavily.
    • Let the doctor know about all medicines [OTC and prescription]-nutritional supplements-herbal products you are taking, and any allergies you have, particularly to anything in this medicine.
    • When you purchase Vytorin and start therapy, remember that it may take up to 2 weeks before the medicine takes proper effect.

    • Whenever you go for any lab tests, inform them that you are taking this medicine, for it can lead to abnormal results in liver tests.

    • Women should take Vytorin only if they are not planning to have a baby. Pregnant women or those who are breastfeeding should not take this medicine, as it can harm the baby. This medicine should be discontinued immediately if pregnancy occurs during treatment.

    • Young girls who want to take this medication, must have had their menstrual periods for at least a year before starting on Vytorin.

    • Those who are also taking Cholestyramine [Questran] should take Vytorin 2 hours before or 4 hours after taking Cholestyramine.

    • Simvastatin increases the effect of anticoagulants [Warfarin] and blood concentration of antidysrrhthmics [Digoxin], so such patients will have to undertake blood tests regularly.

    • It is recommended that you get your blood pressure checked regularly to reduce the risk of heart attack and stroke.

    • If you experience any unexplained muscular weakness/tenderness/ pain accompanied with flu-like symptoms and dark urine, you must contact your physician at once, for it could be a rare breakdown of skeletal muscle tissue that can lead to kidney failure.

    • Those who smoke should refrain from doing so, to keep their arteries unclogged and avert the risk of a heart attack.

    • It is recommended that you walk for about 30 minutes daily; obese people should follow a weight-loss program.

    • This medicine can make you more sensitive to strong light; use sunscreens and protective clothing.

    • Avoid fatty and fried food; ask your doctor to prescribe a healthy diet so that you maintain good health.

    • Most people with high cholesterol/fat levels in their blood do not feel sick while taking Vytorin.


    This medicine is contraindicated if you are taking the following:-
    • Other cholesterol managing agents such as Niacin, Gemfibrozil, or Fenofibrate;

    • Antibiotics like Erythromycin, Clarithromycin, or Telithromycin;

    • Anti-fungals such as Ketoconazole or Itraconazole;

    • Antidepressants like Nefazodone;

    • Protease Inhibitors to treat HIV like Indinavir and Ritonavir.
  • Notes

    Read the Patient Information every time you buy a refill - it may have some new information. Your cardiologist will be able to tell you more about the uses, side effects, interactions, and precautions associated with this medication.

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